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Human milk oligosaccharide 2′-fucosyllactose supplementation improves gut barrier function and signaling in the vagal afferent pathway in mice
2'-Fucosyllactose in human milk improves gut lining and nerve signaling to the brain in mice
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Abstract
Dietary supplementation with (2'-FL) reduced fat mass and energy intake in high-fat fed mice.
- 2'-FL supplementation significantly decreased the HF-induced increase in fat mass and energy intake.
- Intestinal permeability was significantly reduced with 2'-FL supplementation.
- 2'-FL significantly increased the expression of interleukin (IL)-22, which plays a protective role in the intestine.
- Changes in gut microbiota composition and associated microbial metabolites were observed with 2'-FL.
- Signaling in the vagal afferent pathway improved with 2'-FL supplementation, but cognitive function showed no significant change.
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Key numbers
HF/2'-FL vs. HF/CON < 0.05
Decrease in Energy Intake
Energy intake was significantly reduced in 2'-FL supplemented mice on a high-fat diet.
2'-FL supplementation decreased paracellular and transcellular permeability
Improved Gut Barrier Function
2'-FL supplementation significantly improved gut barrier integrity in both diet groups.
Higher c-Fos expression in AP and NTS areas in HF/2'-FL
Activation
2'-FL-treated mice showed increased neuronal activation in response to CCK.