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Hypoxia enhances IL-8 signaling through inhibiting miR-128-3p expression in glioblastomas
Low oxygen increases IL-8 signaling by lowering miR-128-3p levels in aggressive brain tumors
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Abstract
Lower levels of miR-128-3p in hypoxic glioblastoma multiforme are associated with reduced sensitivity to temozolomide treatment.
- miR-128-3p is negatively correlated with hypoxia signaling and the epithelial-mesenchymal transition (EMT) in glioblastoma.
- Hypoxic glioblastoma exhibits lower levels of miR-128-3p, which desensitizes the tumor to temozolomide (TMZ), a standard treatment.
- Overexpression of miR-128-3p increases the sensitivity of hypoxic gliomas to TMZ both in laboratory and animal models.
- HIF-1α suppresses the expression of miR-128-3p in the hypoxic microenvironment of glioblastoma.
- Interleukin (IL)-8 shows a positive correlation with hypoxia and a negative correlation with miR-128-3p, and is linked to poor outcomes with TMZ treatment.
- The interaction between HIF-1α, miR-128-3p, and IL-8 may regulate TMZ sensitivity and the EMT in hypoxic glioblastoma cells.
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