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Identification of the CeRNA axis of circ_0000006/miR-483-5p/KDM2B in the progression of aortic aneurysm to aorta dissection
Role of a specific RNA interaction network in the progression from aortic aneurysm to aortic dissection
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Abstract
Twelve circular RNAs were found to be upregulated in aortic dissection (AD) compared to aortic aneurysm (AA) samples.
- miR-483-5p was downregulated in AD, while its targets KDM2B and circ_0000006 were upregulated.
- Silencing circ_0000006 in vascular smooth muscle cells inhibited key processes associated with disease progression.
- In an aortic dissection mouse model, knocking down circ_0000006 reduced disease progression and induced similar molecular changes.
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Key numbers
12
Upregulated in AD vs. AA
Number of found upregulated in AD samples compared to AA samples.
4 of 4
Patients in Each Group
Number of patients with AA and AD included in the study.