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Changing the dosing schedule minimizes the disruptive effects of interferon on clock function
Changing dosing times reduces interferon's disruption of the body clock
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Abstract
Interferon-alpha disrupts the rhythms of locomotor activity, body temperature, and clock-gene expression.
- Repetitive administration of interferon-alpha negatively affects the rhythmicity of clock genes.
- Changes in clock-gene mRNA expression were observed in both peripheral tissues and the suprachiasmatic nuclei.
- The photic induction of the Per gene in the suprachiasmatic nuclei was disturbed by interferon-alpha.
- Optimizing the dosing schedule may help minimize adverse effects related to clock function disruption.
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