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Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high‐fat diet fed mice
Blocking interleukin 6 improves insulin resistance by increasing muscle glucose use and reduces liver fat in high-fat diet mice
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Abstract
An eight-week high-fat diet increased hepatic triglyceride content, which was reduced by a single injection of an anti-IL-6 receptor antibody.
- A high-fat diet for both 2 and 8 weeks raised plasma levels of IL-6, insulin, and leptin, which were lowered by anti-IL-6 receptor treatment.
- Single injection of the anti-IL-6 receptor antibody improved insulin resistance, potentially through increased glucose transporter type 4 and peroxisome proliferator-activated receptor alpha.
- The treatment also decreased the expression of leptin and tumor necrosis factor-alpha while increasing adiponectin in adipose tissue.
- Only the eight-week high-fat diet led to hepatic steatosis, which was reversed by the anti-IL-6 receptor treatment.
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