Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice

Piperine administration (50 mg/kg body weight) significantly increased plasma adiponectin levels in mice with high-fat diet-induced hepatic steatosis.

• Mice fed a high-fat diet for 13 weeks showed elevated plasma insulin, glucose, and hepatic lipid levels.
• Piperine treatment reversed the increases in insulin, glucose, and hepatic lipids caused by the high-fat diet.
• The down-regulation of adiponectin-AMP-activated protein kinase (AMPK) signaling molecules was reversed with piperine treatment.
• Lipogenic target gene expressions decreased while carnitine palmitoyltransferase 1 (CPT1) expression, linked to fatty acid oxidation, increased in the livers of piperine-treated mice.
• Piperine reduced phosphorylation of insulin receptor substrate-1 (IRS-1) compared to high-fat diet-fed mice.

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