Aligning Intrinsic Capacity and Geroscience: Linking Function with Biology

Intrinsic Capacity (IC) may serve as both a measurable indicator of global function and a potential target for geroscience interventions.

• The World Health Organization defines IC as the composite of all physical and mental capacities.
• Optimizing IC throughout life is suggested as essential for achieving healthy aging.
• Geroscience aims to understand aging biology and develop strategies to slow the aging process.
• Declines in IC domains are associated with the hallmarks of aging.
• Emerging gerotherapeutic approaches may optimize IC and contribute to healthy aging.
• Integrating IC into clinical and public health frameworks could guide preventive and personalized health strategies.

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