Food & functionJan 19, 2022

Lactiplantibacillus plantarum CCFM1019 may reduce polycystic ovary syndrome through a gut-brain process involving butyrate

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 5, 2026

Abstract

CCFM1019 reduced PCOS symptoms in a letrozole-induced model by restoring hormone levels and altering gut microbiota.

CCFM1019 alleviated ovarian pathological changes in a rat model of PCOS.
Restoration of testosterone and luteinising hormone levels was observed with CCFM1019 treatment.
Metabolic disorders induced by letrozole were not significantly reversed by CCFM1019.
Alterations in gut microbial diversity and increases in short-chain fatty acid producers were noted after CCFM1019 intervention.
Rats treated with CCFM1019 showed higher levels of butyrate and polypeptide YY compared to letrozole-treated rats.
A potential gut-brain mechanism involving butyrate regulation may contribute to the protective effects of CCFM1019.

Simplified

Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects women of reproductive age. The gut microbiota has been shown to play a vital role in the pathogenesis of PCOS. Agents that target microbes in the gut may be promising therapeutic strategies for PCOS. Herein, a letrozole-induced PCOS model was used to test fivestrains for their ability to alleviate PCOS symptoms and their effect on the gut-brain axis.CCFM1019 attenuated the pathological changes in the ovaries and restored testosterone and luteinising hormone levels. However, metabolic disorders induced by letrozole treatment were not significantly reversed by these strains. Meanwhile, alteration of gut microbial diversity and enrichment of the short-chain fatty acid producersandwere observed afterCCFM1019 intervention. Compared with letrozole-treated rats, those treated withCCFM1019 exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression. These results demonstrated thatCCFM1019 attenuated letrozole-induced PCOS symptoms in rats. A butyrate-dependent gut-brain mechanism may be involved in this protective effect. Lactiplantibacillus plantarum Lp. plantarum Lachnospira Ruminococcus_2Lp. plantarum Lp. plantarum Lp. plantarum

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Lactiplantibacillus plantarum CCFM1019 may reduce polycystic ovary syndrome through a gut-brain process involving butyrate

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