Lactobacillus acidophilus LA3 may reduce brain inflammation through gut-brain communication

Lactobacillus acidophilus LA3 has been identified as a potent probiotic strain capable of mitigating neuroinflammation.

• LA3 suppressed LPS-induced proinflammatory cytokines in BV-2 microglia more effectively than other strains.
• In a murine model, LA3 alleviated systemic and neuroinflammation, as well as depressive-like behaviors and cognitive impairment.
• LA3 restored blood-brain and gut-vascular barrier integrity, indicating a protective effect on neurological health.
• The probiotic reversed gut microbiota dysbiosis and increased levels of short-chain fatty acid-producing bacteria.
• Indole-3-acetic acid (IAA) levels were promoted in both colonic contents and brain by LA3.
• The anti-inflammatory effects of LA3 are associated with the aryl hydrocarbon receptor (AHR), as demonstrated by the use of an AHR inhibitor.

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