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Abstract
Essence
Some patients preserved or increased lean soft tissue during semaglutide or tirzepatide weight loss when paired with exercise and protein-focused strategies.
Evidence
This case series describes three patients with BMI 32.9-51.9 kg m who used semaglutide or tirzepatide alongside intentional activity, resistance training, and reported protein intakes, with lean soft tissue changes from -6.9% to +5.8%.
Caveat
The uncontrolled three-patient case series cannot separate medication effects from exercise, protein intake, baseline differences, or measurement variability.
Simplified