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Life Cycle and Circadian Rhythms in Central Resident Immunity and Neuropsychiatric Pathology
Daily and Life Cycle Patterns in Brain Immune Cells and Their Links to Mental Health Disorders
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Abstract
The central immune system, or glial system, plays a critical role in neuropsychiatric disorders.
- Glial cells have unique developmental origins and circadian characteristics that influence their functions.
- These immune cells show rhythmic variations in activities such as phagocytosis and neurotransmitter recycling.
- The daily rhythms of glial cells are linked to changes in emotion, cognition, and motor function.
- Oxidative stress and neuroinflammation are shared processes associated with the circadian rhythms of these immune cells.
- The review explores how these characteristics relate to disorders like major depressive disorder and schizophrenia.
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