Linking circadian rhythms to microbiome-gut-brain axis in aging-associated neurodegenerative diseases

Apr 11, 2022Ageing research reviews

How Body Clock Changes Affect Gut Bacteria and Brain Health in Age-Related Brain Diseases

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Abstract

Disruption of circadian rhythms and gut dysbiosis may be closely related to aging-associated neurodegenerative diseases.

  • The microbiota-gut-brain axis is a key area in understanding neurological disorders.
  • Crosstalk between the brain and gut microbiota may occur through the endocrine, immune, and nervous systems.
  • Recent findings indicate that both the composition and daily variation of gut microbiota are influenced by the host's circadian rhythms.
  • Investigating the interaction between circadian rhythms and the microbiome-gut-brain axis could provide new insights into neurodegenerative diseases.

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