When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis

Mar 5, 2020Cell metabolism

How Daily Body Clocks Interact with the Gut Microbiome and Brain in Depression

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Abstract

The gut microbiota is essential for optimal regulation of host circadian pathways.

  • The microbiota-gut-brain axis involves a two-way communication between gut microorganisms and brain function.
  • Gut microbiota composition varies throughout the day and is influenced by the body's circadian rhythms.
  • Disruption of the cyclical interaction between gut microbes and the host can significantly affect disease pathology and severity.
  • Recent findings suggest a link between the microbiota-gut-brain axis and circadian rhythms regarding disease influence.
  • Further research is necessary to understand how these systems interact to affect disease severity and risk.

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