American Heart Association's new ‘Life's Essential 8’ score in association with cardiovascular disease: a national cross-sectional analysis

Nov 17, 2023Public health

How the American Heart Association's new 'Life's Essential 8' score relates to heart disease in the US

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Abstract

The high LE8 group had 82.95% of individuals aged 20-59 years.

Moderate and high LE8 scores are associated with lower odds of cardiovascular disease (CVD).
The odds of CVD are significantly reduced by a one standard deviation increase in the LE8 score (OR: 0.64).
Younger individuals and females show a stronger negative correlation between LE8 scores and CVD.
Stratification analysis indicates a significant relationship between the LE8 score and CVD, particularly among younger adults and women.

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OBJECTIVE: The American Heart Association (AHA) has recently updated and enhanced the quantification of cardiovascular health by using the Life's Essential 8 (LE8) score. We intended to examine the correlation between cardiovascular health status, as measured by the new LE8 score, and cardiovascular disease (CVD) in US adults.

STUDY DESIGN: National cross-sectional study.

METHODS: A total of 24,730 individuals without pregnancy and with complete data from 2007 to 2018 enrolled in the study. The overall LE8 score was divided into low, moderate, and high groups. Multivariate logistic regressions were used to assess the odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between the LE8 score and the presence of CVD.

RESULTS: Overall, the high LE8 group had a younger age (20-59 years, 82.95%) and more females (60.09%) compared to the low LE8 group. Moderate and high LE8 correlated negatively with the presence of CVD (moderate, OR: 0.46, 95% CI: 0.39-0.54; high, OR: 0.26, 95% CI: 0.21-0.33). One standard deviation increment in the LE8 score correlated significantly with lower odds of CVD (OR: 0.64; 95% CI: 0.60-0.69). Further stratification analysis also detected a significant relationship between the new LE8 score and CVD, and the result was enhanced among the young and women (P-interaction<0.001).

CONCLUSIONS: Higher LE8 score correlated with lower odds of CVD, especially among the young and women.

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American Heart Association's new ‘Life's Essential 8’ score in association with cardiovascular disease: a national cross-sectional analysis

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