Associations between Life's Essential 8 and depression among US adults

Jun 8, 2024Psychiatry research

Links between the Life's Essential 8 health factors and depression in US adults

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Better cardiovascular health (CVH), indicated by a high Life's Essential 8 (LE8) score, is associated with a reduced prevalence of depression among US adults.

Moderate CVH is linked to a 55% lower odds of depression compared to low CVH.
High CVH is associated with an 79% lower odds of depression than low CVH.
All eight metrics of LE8 show a negative association with depression.
Nicotine exposure and sleep health are identified as significant contributors to the overall association with depression.
Improving CVH through smoking cessation and adequate sleep may help in reducing depression risk.

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Few studies have examined the association of Life's Essential 8 (LE8) with depression among US adults. This is a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2020. LE8 score was measured as the mean score of eight metrics (diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipid, blood glucose, and blood pressure). CVH was categorized into low, moderate, and high according to tertiles of LE8 score. Depression was defined based on the 9-Item Patient Health Questionnaire (PHQ-9). Weighted logistic regressions were conducted to assess the associations of depression with CVH. Compared with participants with low CVH, the fully adjusted ORs of depression were 0.45 (0.37, 0.55) in the moderate CVH and 0.21 (0.15, 0.30) in the high CVH participants, respectively. The results remained robust in subgroup and sensitivity analyses. All eight LE8 metrics were negatively associated with depression, while nicotine exposure and sleep health were identified as two major metrics contributing to the association. Better CVH evaluated by LE8 was associated with decreased depression prevalence among US adults. Adherence to a higher CVH score, especially targeting smoking cessation and proper sleep duration, might be beneficial for prevention of depression.

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Associations between Life's Essential 8 and depression among US adults

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