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Life’s Essential 8 scores, socioeconomic deprivation, genetic susceptibility, and new-onset chronic kidney diseases
Healthy lifestyle scores, social disadvantage, genetic risk, and new cases of chronic kidney disease
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Abstract
During a median follow-up of 12.5 years, 8,857 participants (3.1%) developed new-onset (CKD).
- Moderate cardiovascular health (CVH) scores (50 ≤ < 80) are associated with a 50% lower risk of new-onset CKD compared to low scores (LE8 < 50).
- High CVH scores (LE8 ≥ 80) are associated with a 69% lower risk of new-onset CKD compared to low scores.
- The population-attributable risk for new-onset CKD associated with high CVH scores is 40.3%.
- Participants with low socioeconomic deprivation have a 25% lower risk of developing new-onset CKD compared to those with high deprivation.
- Those with low genetic risk of CKD have an 11% lower risk compared to individuals with high genetic risk.
- Socioeconomic deprivation and genetic risks do not significantly modify the relationship between LE8 scores and new-onset CKD.
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Key numbers
0.31
Decrease in Risk (High vs. Low )
Adjusted hazard ratio for high scores compared to low scores.
40.3%
Population-Attributable Risk for High Scores
Percentage of new-onset cases preventable if all individuals had high CVH.
8857
New-Onset Cases
Total number of new-onset cases reported during the follow-up.