During a median follow-up of 12.5 years, 8,857 participants (3.1%) developed new-onset (CKD).
Moderate cardiovascular health (CVH) scores (50 ≤ < 80) are associated with a 50% lower risk of new-onset CKD compared to low scores (LE8 < 50).
High CVH scores (LE8 ≥ 80) are associated with a 69% lower risk of new-onset CKD compared to low scores.
The population-attributable risk for new-onset CKD associated with high CVH scores is 40.3%.
Participants with low socioeconomic deprivation have a 25% lower risk of developing new-onset CKD compared to those with high deprivation.
Those with low genetic risk of CKD have an 11% lower risk compared to individuals with high genetic risk.
Socioeconomic deprivation and genetic risks do not significantly modify the relationship between LE8 scores and new-onset CKD.
Simplified
BACKGROUND: The American Heart Association recently released a new cardiovascular health (CVH) metric, (LE8), for health promotion. However, the association between LE8 scores and the risk of (CKD) remains uncertain. We aimed to explore the association of LE8 scores with new-onset CKD and examine whether socioeconomic deprivation and genetic risk modify this association.
METHODS: A total of 286,908 participants from UK Biobank and without prior CKD were included between 2006 and 2010. CVH was categorized using LE8 scores: low (LE8 scores <50), moderate (LE8 scores ≥50 but <80), and high (LE8 scores ≥80). The study outcome was new-onset CKD, ascertained by data linkage with primary care, hospital inpatient, and death data. Cox proportional hazard regression models were used to investigate the association between CVH categories and new-onset CKD.
RESULTS: During a median follow-up of 12.5 years, 8857 (3.1%) participants developed new-onset CKD. Compared to the low CVH group, the moderate (adjusted hazards ratio [HR], 0.50; 95% confidence interval [CI]: 0.47-0.53) and high CVH (adjusted HR, 0.31; 95% CI: 0.27-0.34) groups had a significantly lower risk of developing new-onset CKD. The population-attributable risk associated with high vs. intermediate or low CVH scores was 40.3%. Participants who were least deprived ( vs. most deprived; adjusted HR, 0.75; 95% CI: 0.71-0.79) and with low genetic risk of CKD ( vs. high genetic risk; adjusted HR, 0.89; 95% CI: 0.85-0.94) had a significantly lower risk of developing new-onset CKD. However, socioeconomic deprivation and genetic risks of CKD did not significantly modify the relationship between LE8 scores and new-onset CKD (both P -interaction >0.05).
CONCLUSION: Achieving a higher LE8 score was associated with a lower risk of developing new-onset CKD, regardless of socioeconomic deprivation and genetic risks of CKD.
Key numbers
0.31
Decrease in Risk (High vs. Low )
Adjusted hazard ratio for high scores compared to low scores.
40.3%
Population-Attributable Risk for High Scores
Percentage of new-onset cases preventable if all individuals had high CVH.
8857
New-Onset Cases
Total number of new-onset cases reported during the follow-up.
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