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Lipidome profiles and sleep disorders: A Mendelian randomization analysis of insomnia, sleep terrors, sleep apnea, and circadian rhythm disturbances
Links between fat molecule patterns and sleep problems: genetic analysis of insomnia, night terrors, sleep apnea, and body clock issues
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Abstract
Significant causal associations were found between specific lipid species and sleep disorders, including insomnia, sleep terrors, and sleep apnea.
- For insomnia, certain lipid species such as sterol ester (27:1/20:3) and ceramides (d40:1, d42:1, d42:2) may have protective effects.
- Phosphatidylcholines (16:0_22:4, O-16:0_16:1, O-16:0_18:2) and sphingomyelin (d34:0) are associated with increased risk for sleep terrors, while triacylglycerol (46:2) could provide protection.
- Cholesterol levels appear to have a protective effect against sleep apnea, whereas specific phosphatidylcholines (16:1_18:0) and triacylglycerols (52:2, 52:3, 58:8) are linked to increased risk.
- Circadian rhythm disturbances may be influenced by various lipid species, with diacylglycerol (18:1_18:3) and phosphatidylcholine (16:1_18:0) increasing risk, while phosphatidylethanolamines (O-16:1_20:4, O-18:1_20:4) may be protective.
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Key numbers
0.911
Protective for Insomnia
for sterol ester (27:1/20:3) related to insomnia risk.
3.275
Increased Risk for Sleep Terrors
for phosphatidylcholine (O–16:0_16:1) associated with sleep terror risk.
0.96
Protective for Sleep Apnea
for cholesterol related to sleep apnea risk.