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Lipopolysaccharide derived from the digestive tract triggers an inflammatory response in the uterus of mid-lactating dairy cows during SARA
Digestive tract bacterial toxins trigger uterine inflammation in dairy cows during mid-lactation with SARA
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Abstract
The high-concentrate diet led to significantly higher lipopolysaccharide (LPS) concentrations in both rumen and plasma compared to the low-concentrate diet.
- Cows on the high-concentrate diet exhibited lower ruminal pH than those on the low-concentrate diet.
- Increased levels of pro-inflammatory cytokines, including IL-1β, TNF-α, and IL-6, were observed in cows on the high-concentrate diet.
- The uterus of cows experiencing subacute ruminal acidosis (SARA) showed elevated mRNA levels of nuclear transcription factors and pro-inflammatory cytokines.
- Protein expression of NF-κB-p65 and its active phosphorylated form was increased in the uterus of SARA cows.
- Key inflammatory genes associated with the immune response were significantly upregulated in the uterus of cows fed a high-concentrate diet.
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