Lithium affects the circadian clock in the choroid plexus – A new role for an old mechanism

Lithium chloride significantly delayed the phase and prolonged the period of the circadian clock in the choroid plexus.

• Lithium chloride influenced the expression of the clock gene Nr1d1 in the choroid plexus.
• A dose-dependent effect of lithium on the circadian clock was observed in organotypic explants.
• Different responses were noted in clock parameters when comparing lithium with inhibitors of specific kinases.
• Lithium-induced phase delays were reduced by an inhibitor of protein kinase C, indicating its potential role in the mechanism.
• The findings suggest that lithium may help synchronize the function of the choroid plexus clock with the sleep-wake cycle.

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