Characterization of the circadian oscillator in the choroid plexus of rats

Feb 4, 2020Biochemical and biophysical research communications

Daily biological clock in the fluid-producing brain tissue of rats

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Abstract

The intrinsic circadian period of the choroid plexus in the lateral ventricle and fourth ventricle is approximately 21 hours.

  • The choroid plexus acts as a circadian oscillator, integrating with the master clock located in the suprachiasmatic nucleus.
  • Circadian phases of the choroid plexus are positioned between those of the pineal gland and the suprachiasmatic nucleus.
  • Variations in the expression of the gene rPer2 in choroid plexus epithelial cells show a dusk-to-dawn pattern.
  • The choroid plexus may influence the secretion of cerebrospinal fluid.
  • No variation in the expression of the water channel aquaporin 1 was detected.

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