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The choroid plexus harbors a circadian oscillator modulated by estrogens
A daily biological clock in the brain’s fluid-producing tissue influenced by estrogen
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Abstract
The choroid plexus exhibits endogenous circadian rhythms of PERIOD2::LUCIFERASE expression.
- Core clock genes in the choroid plexus are regulated by circadian rhythms in a sex-dependent manner.
- Estrogen levels affect the daily rhythm of clock gene expression, particularly Bmal1, Per1, and Per2, in female rat choroid plexus.
- Ovariectomy leads to a decline in estrogen, which alters the rhythmic expression of these clock genes.
- The estrogen receptor is involved in mediating the response of clock genes to estrogen.
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