Biogerontology

Melatonin’s role in fixing age-related changes in daily patterns of clock gene activity in the brain’s timekeeping center of male rats

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Aging in male Wistar rats is associated with significant alterations in the daily rhythms of clock gene expression in the suprachiasmatic nucleus.

  • In adult rats (3 months), all studied clock genes exhibited rhythmic expression patterns.
  • Maximum mRNA expression levels were observed for rPer1 at ZT-6, rPer2, rCry1, and rCry2 at ZT-12, and rBmal1 at ZT-18.
  • In 12 and 24-month-old rats, the phases of expression for these clock genes were significantly disrupted.
  • Daily rhythms of rCry1, rCry2, and rBmal1 were abolished in 24-month-old rats.
  • Melatonin treatment restored the daily rhythms and expression levels of clock genes in various age groups.
  • The study indicates differential effects of melatonin on gene expression rhythms in aging rats.

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