Biogerontology

Curcumin's effects on age-related changes in daily gene rhythms and Sirt1 levels in the brain's biological clock of male rats

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Updated

Abstract

Curcumin treatment restored the daily rhythms of several clock genes in middle-aged and old male Wistar rats.

  • Age-related oxidative stress may disrupt biological clock function by affecting gene expression in the suprachiasmatic nucleus (SCN).
  • Alterations in clock gene expression were observed in young (3 months), middle-aged (12 months), and old (24 months) rats.
  • Curcumin administration restored the rhythm and expression levels of clock genes such as rPer1, rPer2, rCry1, and rCry2 in middle-aged rats.
  • In old rats, curcumin treatment led to the restoration of rPer1 phase and daily pulse.
  • Correlations among clock genes were altered in aged control groups but partially restored with curcumin treatment in middle-aged and old rats.
  • Interconnections between rSirt1 and clock genes were disrupted with aging, and curcumin treatment resulted in partial recovery of these interactions.

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