Journal of neurochemistry

Morphine withdrawal changes daily patterns of biological clock genes in brain reward areas and blood cells in rats

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Updated

Abstract

Chronic morphine withdrawal led to desynchronization of clock gene expression in the central nervous system and peripheral blood mononuclear cells.

  • Rats exhibited clear withdrawal signs, including teeth chattering and weight loss, 14 hours after the last morphine dose.
  • Expression of rPER1 and rPER2 showed robust circadian rhythms in most brain regions of morphine-treated rats, similar to control rats.
  • In the ventral tegmental area, rPER1 expression was completely phase-reversed in morphine-treated rats.
  • Blunting of circadian oscillations for rPER1 occurred in the central amygdala, hippocampus, nucleus accumbens core, and PBMCs of morphine-treated rats.
  • rPER2 expression was also blunted in the central amygdala, prefrontal cortex, nucleus accumbens core, and PBMCs following morphine treatment.
  • rCLOCK expression did not show rhythmic changes in morphine-treated rats, remaining similar to controls.

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