Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain

May 3, 2005Journal of biomedical science

Daily patterns of key internal clock genes in the rat brain

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Abstract

High densities of mRNA for three rhythm-related genes are found in the rat hypothalamic suprachiasmatic nucleus (SCN).

  • Expression of rPeriod1 (rPer1), rPeriod2 (rPer2), and rClock mRNA was examined in various brain regions of male Sprague-Dawley rats.
  • Diurnal rhythmicity of rPer1 and rPer2 mRNA levels was observed in the SCN, arcuate nucleus, and median eminence/pars tuberalis.
  • Distinct expression patterns for rPer1 and rPer2 were noted in these brain regions, indicating varying physiological roles.
  • No rhythmicity for rPer1 or rPer2 was found in the cerebellum or hippocampus.
  • Diurnal changes in rClock mRNA expression were not detected in any brain region studied.

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