Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats

Apr 7, 2020Biogerontology

Withania somnifera leaf extract may improve age-related daily rhythm changes in key proteins of the brain’s internal clock in male rats

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Abstract

Withania somnifera treatment restored daily rhythms of SIRT1 and NRF2 in aging rats.

  • Daily rhythms of rNrf2 expression showed a 6-hour phase delay in middle-aged and a 12-hour phase advance in old-aged rats.
  • WS restored daily rhythms and phase of rSirt1 in old-aged rats and phase of rNrf2 in both middle-aged and old-aged rats.
  • At the protein level, SIRT1 expression advanced in middle-aged and old-aged rats, while NRF2 daily rhythms were disrupted in both groups.
  • WS treatment restored the phase and daily rhythms of SIRT1 and NRF2 in 12-month-old rats.
  • The expression of rRev-erbα was unchanged by WS treatment across all age groups.
  • Correlation analysis indicated significant interactions among rSirt1, rNrf2, and rRev-erbα in young rats that altered with aging.

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