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A TTX‐sensitive local circuit is involved in the expression of PK2 and BDNF circadian rhythms in the mouse suprachiasmatic nucleus
A local nerve circuit sensitive to TTX helps control daily rhythms of PK2 and BDNF in the mouse brain's clock center
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Abstract
Tetrodotoxin treatment abolished the circadian rhythm of BDNF mRNA levels in the suprachiasmatic nucleus (SCN) of adult mice.
- The expression of clock genes Per1, Per2, Bmal1, and Cry1 was not affected by tetrodotoxin treatment.
- Clock-associated genes Dec1, Dec2, Rev-erbalpha, Rev-erbbeta, and DBP maintained their circadian rhythms despite tetrodotoxin application.
- Tetrodotoxin significantly dampened the circadian rhythm of PK2 mRNA levels.
- The AVP mRNA levels did not show significant changes following tetrodotoxin treatment.
- Input through sodium channel-dependent neuronal activity is not necessary for the expression of circadian rhythms of clock and clock-associated genes.
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