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Aging renders desynchronization between clock and immune genes in male Wistar rat kidney: chronobiotic role of curcumin
Aging disrupts timing between body clock and immune genes in male rat kidneys, which may be helped by curcumin
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Abstract
Significant phase alterations and increased mean 24-hour levels were observed in immune genes in aging kidneys.
- The study monitored mRNA expression of various clock and immune genes in the kidneys of male Wistar rats at 3, 12, and 24 months.
- No significant changes were found in most clock genes, except for rRorĪ±.
- Immune genes exhibited significant phase alterations and increased mean levels across the aging process.
- A desynchronization was noted between the expression of immune and clock genes.
- Curcumin administration was evaluated for its potential chronobiotic effects on the daily rhythms of clock and immune gene expression.
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