Circadian expression of clock genes in the rat eye and brain.

Jan 5, 2007Molecules and cells

Daily patterns of internal clock genes in the rat eye and brain

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Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗

Abstract

The expression of rPer1 and rPer2 mRNAs in the rat's suprachiasmatic nucleus follows a clear circadian rhythm.

  • Clock genes rPer1 and rPer2 in the SCN show circadian expression patterns alongside rCry1 and rCry2.
  • The levels of BMAL1 and CLOCK mRNAs decrease during the day and increase at night with low amplitude.
  • Eye tissue exhibits circadian rhythms for rCry1 and rCry2, increasing during subjective day and decreasing during subjective night.
  • Opn4 mRNA levels are higher during the day but do not display a clear circadian expression pattern.
  • Cryptochromes in the eye may play a primary role in synchronizing the SCN's circadian rhythm, rather than melanopsin.

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