Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson’s disease model in male Wistar rat and its modulation by melatonin

Jun 4, 2017Biogerontology

Daily protein changes in aging and Parkinson's-like rats and how melatonin influences them

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

In 3-month-old rats, the number of proteins showing day-night variations in the suprachiasmatic nucleus and substantia nigra was greater than in 12-month, 24-month, and rotenone-induced Parkinson's disease models.

  • Aging is associated with changes in the circadian timing system, leading to dysfunction.
  • Significant alterations in core clock gene expression levels were observed in aging and Parkinson's disease models.
  • In pineal glands, an increase in proteins with day-night variations was noted in 24-month-old rats.
  • Melatonin administration may modulate the chronomics of protein profiles in aging and Parkinson's disease.
  • Several proteins exhibiting significant day-night variations were identified for the first time in this study.

AI simplified

Full Text

Full text is available at the source.
View full text (HTML) ↗View full text (PDF) ↗

Related papers

Nov '14
Daily patterns of serotonin and body clock genes in the brain's time-keeping center in a Parkinson’s rat model and how melatonin may affect them
top 20% journal
cited by 56 papers
research support, non-u.s. gov't
Mar '14
Melatonin’s role in fixing age-related changes in daily patterns of clock gene activity in the brain’s timekeeping center of male rats
top 20% journal
cited by 56 papers
research support, non-u.s. gov't
Dec '14
Melatonin affects daily serotonin metabolism changes with aging in the brain’s internal clock of male rats
top 20% journal
cited by 24 papers
comparative study
Sep '09
Melatonin’s effects on age-related changes in daily serotonin rhythms in the brain’s internal clock of male rats
top 20% journal
cited by 40 papers
research support, non-u.s. gov't
Sep '12
Melatonin affects daily changes in liver oxidative stress and antioxidants differently with age in male rats
top 20% journal
cited by 59 papers
research support, non-u.s. gov't
Sep '07
Curcumin's effect on alcohol-related changes in the brain's biological clock and hormone gland
cited by 35 papers
research support, non-u.s. gov't
Dec '05
Different parts of the body’s internal clock respond differently to melatonin
top 30% journal
cited by 7 papers
journal article
Nov '22
Daytime-limited feeding differently affects age-related changes in serotonin processing in the brain's biological clock and the pineal gland of male rats
top 20% journal
cited by 6 papers
research support, non-u.s. gov't
Jan '03
How the brain’s internal clock controls melatonin production in rats through activating and blocking signals
top 20% journal
cited by 157 papers
research support, non-u.s. gov't
Sep '16
Daily nitric oxide patterns in body clocks of aging male rats and protective effects of melatonin
top 20% journal
cited by 22 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #35
Bacteria exposure resets your internal clock independently of immune responses
2 days ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
1 week ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
2 weeks ago7 studies
issue #32
Bright light preference disrupts mouse sleep patterns even without human lifestyle factors
3 weeks ago7 studies
issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
4 weeks ago7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
5 weeks ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
6 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
7 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
8 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief