A low-protein diet eliminates the circadian rhythm of serum insulin and hepatic lipid metabolism in mice

Mice fed a low-protein diet for 7 days displayed lower insulin secretion and disrupted hepatic lipid metabolism.

• Mice on a low-protein diet showed enhanced food intake at the end of the light phase.
• Serum insulin levels remained low during the day in low-protein diet mice, with a significant reduction during an oral glucose tolerance test.
• Hepatic triglyceride accumulation occurred at night alongside elevated levels of certain lipid-related gene expressions.
• Hepatic IRS-2 expression was consistently low during the day in low-protein diet mice, with no increase at the light phase's onset.
• The low-protein diet appeared to disrupt the normal circadian rhythm of insulin and hepatic lipid metabolism.

AI simplified