Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet

No SJR dataNov 2, 2020Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Identifying LSD-like Chemicals 1cP-LSD, MIPLA, and 1B-LSD in Illegal Paper Products

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Abstract

Three additional LSD derivatives were detected in paper sheet products from Japan.

The detected derivatives include 1cP-LSD, MIPLA, and 1B-LSD.
These substances were identified through high-resolution mass spectrometry techniques.
1cP-LSD and 1B-LSD may convert back to LSD during analysis, requiring careful evaluation.
The findings expand the understanding of LSD derivative prevalence in global designer drug markets.

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Lysergic acid diethylamide (LSD) is a hallucinogen, synthesized from ergot alkaloid, and controlled as a narcotic in Japan. Recently, LSD derivatives have appeared as designer drugs, all over the world. In previous study, we reported identification and analysis of four LSD derivatives in four paper sheet products. In this study, we detected three additional LSD derivatives from three paper sheet products, which were obtained from September 2019 to March 2020 in Japan. We extracted the compounds from paper sheet products with methanol for LC-MS, high-resolution MS and GC-MS analyses. The compounds were identified as 4-cyclopropionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1cP-LSD), N-methyl-N-isopropyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo-[4,3-fg]quinoline-9-carboxamide (MIPLA), 4-butyryl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1B-LSD), by GC-MS, LC-MS, LC-Q-TOF-MS and NMR analyses. As well as other N1-acylated LSD derivatives, 1cP-LSD and 1B-LSD were easily deacylated to LSD during GC-MS analysis, we have to be careful to analyze these compounds.

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