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Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2
Different roles of cryptochrome 1 and 2 in controlling daily rhythm genes and body clock timing
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Abstract
Cry1(-/-) mice exhibited a circadian period 1 hr shorter than wild type, while Cry1(-/-)Cry2(-/-) mice were arrhythmic in constant darkness.
- Cry1 and Cry2 are necessary for normal circadian behavioral rhythms in mice.
- The absence of Cry1 led to a shortened circadian period, while the lack of both Cry1 and Cry2 resulted in arrhythmic behavior.
- Light induction of the mPer1 gene in the brain's circadian center was reduced in Cry1(-/-) mice and completely abolished in Cry1(-/-)Cry2(-/-) mice.
- mPer2 expression remained unaffected by the absence of Cry1 and Cry2 under light induction conditions.
- In double mutants, mPer1 levels were consistently high with no rhythmicity, while mPer2 displayed rhythmicity in light but not in darkness.
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