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Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock
Light-triggered mPer1 and mPer2 gene activity in mice without a working biological clock
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Abstract
Mice lacking mCry1 and mCry2 exhibit abolished cyclic expression of clock genes mPer1 and mPer2.
- Behavioral rhythms are absent in mice without mCry1 and mCry2.
- High levels of mPer1 and mPer2 mRNA are consistently present in these mice.
- The elimination of the biological clock is linked to the absence of both mCRY1 and mCRY2.
- Mice lacking these proteins can still respond to light stimuli that phase-shift the biological clock.
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