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Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses
Role of a blue-light sensor in mice for regulating daily biological rhythms
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Abstract
Mice lacking the cryptochrome 2 gene had an intrinsic circadian period about 1 hour longer than normal.
- Mutant mice showed lower sensitivity to light-induced activation of a specific gene related to the circadian clock.
- Normal circadian oscillations of certain messenger RNA levels were observed in the suprachiasmatic nucleus of mutant mice.
- High-amplitude phase shifts were noted in the mutants in response to light pulses at a specific circadian time.
- Findings support the idea that cryptochrome 2 may influence circadian responses in mammals.
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