Managing patients taking glucagon-like peptide-1 receptor agonists: proceed with caution

Oct 29, 2025British journal of anaesthesia

Careful management of patients using glucagon-like peptide-1 receptor agonists

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Abstract

A significant association was found between glucagon-like peptide-1 (GLP-1) receptor agonist use and impaired gastric emptying events.

  • Impaired gastric emptying may increase the risk of perioperative pulmonary aspiration.
  • The study analyzed data from the US Food and Drug Administration Adverse Event Reporting System database.
  • Recent guidelines recommend that most patients can continue GLP-1 receptor agonists before surgery.
  • Patients at high risk for gastrointestinal issues may need to follow a 24-hour liquid diet prior to surgery.
  • Identifying which patients are at high risk for aspiration remains a challenge.

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