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Abstract
Analysis of 25,306 post-mortem biopsies reveals distinct patterns of organ structural aging across various tissues in individuals aged 21-70 years.
- Organ structural aging progresses along unique, nonlinear paths for different tissues.
- Vascular tissue shows early acceleration in structural aging, while uterus and vagina accelerate later, around menopause.
- Some tissues, like those in the digestive and male reproductive systems, exhibit biphasic accelerations in aging.
- Increased inflammation is observed alongside decreased energy production, repair, and quality control as structural aging accelerates.
- Cross-organ analysis indicates a coordinated deterioration among tissues within individuals, influenced by sex hormones.
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