Full text is available at the source.
Effects of Medial Hypothalamic Lesions on Feeding-Induced Entrainment of Locomotor Activity and Liver Per2 Expression in Per2::luc Mice
How damage to the middle hypothalamus affects feeding-related daily activity patterns and liver clock gene expression in mice
AI simplified
Abstract
Lesions in the large mediobasal hypothalamus significantly reduce daily locomotor activity rhythms and anticipatory activity formation.
- Destruction of the dorsomedial hypothalamus and surrounding areas leads to decreased daily movement patterns in mice.
- The peak expression of a liver clock gene (Per2) is phase advanced by 2 hours in mice with hypothalamic lesions compared to those with sham operations.
- Lesioned mice exhibit reduced running activity and delayed onset of activity in response to restricted feeding schedules.
- The hypothalamus is essential for sustaining locomotor rhythms and anticipatory activity, but not for the liver clock's response to restricted feeding.
AI simplified