Melatonin regulates circadian clock proteins expression in allergic airway inflammation

In allergic airway inflammation, the expressions of circadian clock proteins were notably up-regulated in the lungs of mice compared to controls.

• Airway inflammation was established in female C57BL/6 mice using ovalbumin (OVA).
• Melatonin treatment reduced OVA-induced airway inflammation and increased the expression of the circadian proteins Per1 and Clock.
• In allergic mice, the levels of melatonin biosynthetase proteins and lung melatonin were reduced, while melatonin receptor expression was increased.
• Treatment with the melatonin receptor antagonist Luzindole increased airway inflammation and decreased the expression of other circadian clock proteins.
• The findings suggest that Per1 may be a target for melatonin in regulating Th2-type airway inflammation.

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