Melatonin helps reverse metabolic problems caused by high fructose in rats

Daily administration of melatonin at 10 mg/kg significantly improved metabolic syndrome in male Wistar rats fed a high fructose diet.

• High fructose intake (60%) for 4 or 6 weeks increased serum insulin, triglycerides, total cholesterol, and other metabolic indicators.
• The high fructose diet led to insulin resistance, as indicated by changes in insulin response and specific resistance indices.
• Melatonin administration reduced the adverse effects of the high fructose diet, particularly at the higher dosage of 10 mg/kg.
• Rats on the high fructose diet showed altered glucose metabolism, evidenced by a higher serum insulin response during glucose tolerance testing.
• After melatonin treatment, improvements were noted in serum insulin response curves and indices of insulin resistance.

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