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Mendelian randomization analysis using GWAS and eQTL data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basis
Genetic analysis of how sleep timing relates to mental health disorders and their molecular causes
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Abstract
Evening chronotype is causal for increased risk of schizophrenia and autism spectrum disorder.
- A bidirectional relationship exists between chronotype and neuropsychiatric disorders.
- Schizophrenia is associated with a tendency toward evening chronotype.
- Data from the largest genome-wide association studies were utilized to explore these relationships.
- Twelve specific genetic variants were identified as having causal roles in the phenotypes studied.
- Gene expression changes in brain or blood could influence the risk for schizophrenia.
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