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The metabolic dialogue between intratumoural microbes and cancer: implications for immunotherapy
Metabolic interactions between microbes inside tumors and cancer linked to immunotherapy
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Abstract
Intratumoural microbial metabolites may significantly influence the tumour microenvironment and cancer immunotherapy outcomes.
- Intratumoural microbiota and their metabolites are crucial in shaping the tumour microenvironment.
- Microbial-derived metabolites such as glucose, amino acids, and lipids can modulate immune cell function and cytokine secretion.
- Specific metabolites, including lactate, short-chain fatty acids, bile acids, and tryptophan derivatives, are associated with regulating immune responses and tumour growth.
- There is potential for these metabolites to enhance the effectiveness of cancer immunotherapies, especially immune checkpoint inhibitors.
- The review examines mechanisms by which microbial metabolites affect the tumour microenvironment, suggesting new microbiome-based therapeutic strategies.
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