Microbiome and NAFLD: potential influence of aerobic fitness and lifestyle modification

Nonalcoholic fatty liver disease (NAFLD) is associated with rising prevalence rates in the US and worldwide.

• NAFLD includes a range of liver conditions from simple fat accumulation to severe inflammation and scarring.
• The gut microbiome may play a critical role in the development and management of NAFLD and related metabolic diseases.
• Diet-induced obesity can cause significant changes in the gut microbiome, leading to the production of metabolites that affect liver metabolism.
• Lifestyle changes, such as improved diet and increased exercise, can positively impact NAFLD outcomes and alter the gut microbiome.
• There is a need for further understanding of how lifestyle-induced changes in the microbiome relate to NAFLD development and progression.

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