Microbiota metabolites affect sleep as drivers of brain‑gut communication (Review)

Jul 4, 2025International journal of molecular medicine

Gut bacteria products may influence sleep by affecting brain-gut communication

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Abstract

The study explores connections between gut microbiota metabolites and sleep disorders.

  • Gut microbiota metabolites may play a significant role in communication between the gut and the brain.
  • Tryptophan and dietary fiber metabolism are highlighted as key sources of these metabolites.
  • Potential pathways suggest interactions between sleep and gut microbiota metabolites.
  • The feasibility of using gut microbiota interventions to address sleep disorders is evaluated.

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