The Crosstalk Between miRNA and Mammalian Circadian Clock

Feb 28, 2015Current medicinal chemistry

Interaction between microRNA and the body's daily biological clock

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Abstract

Circadian clocks regulate daily rhythms in physiology and behavior through complex molecular mechanisms.

  • Circadian rhythms are driven by interlocked feedback loops that influence gene expression of core clock genes.
  • Regulation of circadian clocks involves transcriptional, posttranscriptional, and post-translational mechanisms.
  • miRNAs have been identified as significant regulators of various aspects of circadian clock function.
  • Recent findings highlight the interplay between miRNAs and the mammalian circadian clock.
  • Future research may explore the role of miRNAs in circadian timing related to health and disease.

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