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Micro-Managing the Circadian Clock: The Role of microRNAs in Biological Timekeeping
How microRNAs help control the body's internal clock
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Abstract
Circadian timekeeping mechanisms are present in virtually all living organisms to coordinate daily rhythms in physiology and behavior.
- Circadian clock regulation involves complex interactions beyond simple feedback loops, including posttranscriptional, translational, and posttranslational mechanisms.
- MicroRNAs (miRNAs) play a critical role in regulating various aspects of circadian clock function.
- Research on miRNA-dependent regulation of the circadian timing system has been observed in multiple organisms, including flies, mammals, and higher plants.
- Future research may focus on the role of miRNAs and noncoding RNAs in the circadian regulation of health and disease.
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