MicroRNA-mediated regulation in the mammalian circadian rhythm

May 5, 2012Journal of theoretical biology

How microRNAs help control the daily biological clock in mammals

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Abstract

A computational model predicts that miRNA-mediated regulation plays critical roles in modulating the circadian clock.

  • The model incorporates four genes (Per, Cry, Bmal1, and Clock) and two miRNAs (miRNA-219 and miRNA-132).
  • Incorporating miRNAs into the classic model reveals their post-transcriptional roles in the circadian rhythm.
  • The model aligns with experimental observations regarding the influence of miRNAs on circadian rhythms.
  • Parameter sensitivity analysis suggests that miRNA-mediated regulation may enhance the robustness of circadian rhythms.

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