Invited Review: Regulation of mammalian circadian clock genes

Feb 14, 2002Journal of applied physiology (Bethesda, Md. : 1985)

How genes control the daily biological clock in mammals

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Abstract

The circadian clock operates on an approximately 24-hour cycle and regulates various physiological and behavioral systems.

  • Circadian rhythms are generated by periodic activation of specific clock genes.
  • Clock genes are involved in regulating not only their own expression but also other biochemical processes.
  • Recent advances in genetics and molecular biology have improved the understanding of the molecular mechanisms underlying the circadian clock in mammals.

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