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Milk fat globule membrane and its component phosphatidylcholine induce adipose browning both in vivo and in vitro
Milk fat membrane and its phosphatidylcholine promote fat tissue turning into heat-producing cells in living organisms and lab tests
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Abstract
MFGM decreased fasting glucose and serum insulin levels in high-fat diet-fed mice.
- MFGM improved glucose tolerance and insulin sensitivity in mice on a high-fat diet.
- The induction of brown-like adipocytes in white adipose tissue was stimulated by MFGM and its component phosphatidylcholine (PC).
- In vitro experiments indicated that MFGM and PC increased the expression of proteins associated with thermogenesis.
- MFGM and PC enhanced mitochondrial activity by increasing mitochondrial DNA copy number and oxygen consumption rate.
- Inhibition of PPARĪ± reduced the effects of PC on brown-like adipocyte formation, suggesting its involvement in this process.
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