Journal of biological rhythms

miR-124 helps set the timing of adult daily activity patterns during fruit fly development

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Loss of the microRNA results in significant miswiring within the circadian neural network.

  • Circadian misalignment may negatively impact animal wellbeing and survival.
  • Loss of the microRNA advances evening locomotor activity by several hours in constant darkness.
  • Under a light/dark cycle with a short photoperiod, loss of the microRNA delays morning activity.
  • Elimination of the microRNA during larval development leads to opposite phase phenotypes, but not when lost during pupation to adulthood.
  • The loss of the microRNA alters activity rhythms in specific neurons that control morning and evening activity.
  • Silencing certain neurons in mutant flies can restore evening activity timing, while activating others can rescue both morning and evening timing.

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Competing interests

Conflict of Interest StatementThe authors have no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
PubMed

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